Genetic Defects in 10 Index Cases of Inherited Vitamin K Dependent Clotting Factors Deficiency
نویسندگان
چکیده
منابع مشابه
Hereditary combined deficiency of the vitamin K-dependent clotting factors
Hereditary combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X as well as natural anticoagulants protein C, protein S and protein Z. The spectrum of bleeding symptoms ranges from mild to severe with onset in the neonatal period in severe cases. The bleeding sympt...
متن کاملFamilial deficiency of vitamin K-dependent clotting factors.
Combined deficiency of vitamin K-dependent clotting factors II, VII, IX and X (and proteins C, S, and Z) is usually an acquired clinical problem, often resulting from liver disease, malabsorption, or warfarin overdose. A rare inherited form of defective gamma-carboxylation resulting in early onset of bleeding was first described by McMillan and Roberts in 1966 and subsequently has been termed '...
متن کاملA case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K
Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin. In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated. Case We present a rare case of 43 year woman with acquired vitamin K deficiency and se...
متن کاملProcoagulant Vitamin K-dependent Clotting Factors
We have evaluated the contribution of depression of individual procoagulant vitamin K-dependent clotting factors to the ability of warfarin to protect rabbits against tissue factor-induced coagulation. Mean activities of individual procoagulant factors were determined, in assays with rabbit substrates, for a group of rabbits achieving a protective degree of anticoagulation with warfarin. Values...
متن کاملStructure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors.
ODULES* homologous to the epidermal growth M factor (EGF) precursor have been found in a large number of proteins with diverse functions. Among these proteins are the vitamin K-dependent clotting factors VII, IX, and X, proteins C and S of the protein C anticoagulant system, and the nonvitamin-K-dependent proteins urokinase (uPA), tissue-type plasminogen activator (tPA), and factor XI1 (Fig l)....
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v126.23.4705.4705